Toward a Broader – But Still Rigorous – Definition of Leader Integrity: Commentary

[Excerpt] The impetus for this special issue of The Leadership Quarterly grew out of the desire of a small but enthusiastic group of leadership scholars who were interested in the concepts of integrity in general and behavioral integrity (the consistency between words and actions) in particular. Guest Editor Tony Simons\u27 (2002) theoretical article in Organization Science had sparked a great deal of interest in behavioral integrity, including the interest of a then-doctoral student at Binghamton University, Guest Editor Mike Palanski. Palanski was seeking advice for his dissertation, and Simons wished to build a cadre of scholars with an interest in leader behavioral integrity. A year or so later, Palanski had the “misfortune” of presenting a paper on integrity as the final presenter in the final session on the final day of the 2006 Academy of Management conference in Atlanta. To his surprise, the room was packed, and it quickly became clear that others also wished to study leader integrity in more depth

Energy-Efficient Thermal-Aware Scheduling for RT Tasks Using TCPN

This work leverages TCPNs to design an energy-efficient, thermal-aware real-time scheduler for a multiprocessor system that normally runs in a low state energy at maximum system utilization but its capable of increasing the clock frequency to serve aperiodic tasks, optimizing energy, and honoring temporal and thermal constraints. An off-line stage computes the minimum frequency required to run the periodic tasks at maximum CPU utilization, the proportion of each task''s job to be run on each CPU, the maximum clock frequency that keeps temperature under a limit, and the available cycles (slack) with respect to the system with minimum frequency. Then, a Zero-Laxity online scheduler dispatches the periodic tasks according to the offline calculation. Upon the arrival of aperiodic tasks, it increases clock frequency in such a way that all periodic and aperiodic tasks are properly executed. Thermal and temporal requirements are always guaranteed, and energy consumption is minimized

Iron Sharpens Iron: A Student’s Perspective on Diversity Outreach

POWER (Providing the Outside World with Empowerment and Resources), a student organization within the Texas Tech’s Collegiate Recovery Program established December 2015, elaborated on their members experience when engaging in the important effort of diversity outreach to persons in recovery from substance and alcohol use disorders and eating disorders.  POWER describes their mission statement to provide a foundation and a voice for underrepresented individuals in recovery by delivering positive end results through opportunities for success with a vision to instill hope for a promising future. These members along with the director of the CCRC and another staff member shared what they have found to be most effective and ineffective when presenting to diverse groups in their community. The presenters provided educational and recovery resources used in reaching out but also the varying and tailored approaches and techniques utilized when conducting outreach work to specific marginalized populations.  These materials and techniques have been honed through many presentations and experience since 2015.  During their presentation, student leaders, and members of POWER, shared their own personal experiences of marginalization as well as their experience as presenters/peer leaders

Why Employees Do Bad Things: Moral Disengagement And Unethical Organizational Behavior

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90243/1/j.1744-6570.2011.01237.x.pd

Diversidad de Myxomycetes en zonas áridas de Perú, parte II: el cardonal y las zonas de transición

The results obtained from a second survey for Myxomycetes in the arid areas of Peru are reported. A total of 37 localities from the cactus belt (‘cardonal’), between 1500 and 3000 m a.s.l., were sampled over six years. This survey is based on 601 identifiable collections of myxomycetes, developed in the field under natural conditions or those that were recovered from moist chamber cultures. In total, 84 taxa representing 19 genera were recorded. One new species, Cribraria spinispora Lado & D.Wrigley sp. nov., is described, three species new to South America and 22 additional new species for Peru are reported as well. Endemic plants, expecially cacti, had a particular relevance as myxomycete substrates. The predominance of the order Physarales T.Macbr. in arid areas is reinforced. Comments are included on some collections, as well as SEM micrographs of several species. A statistical evaluation of the diversity of myxomycetes in the cardonal area and a comparison of this area with the dry coastal desert of Peru and other Neotropical xeric environments are also included. Results show that the arid areas are rich in myxomycetes, and that each area has a unique assemblage. The differences appear to be related to the host plants.Se presentan los resultados de un segundo estudio sobre Myxomycetes de zonas áridas de Perú. Un total de 37 localidades del cardonal, situadas entre 1500 y 3000 m s.n.m., fueron muestreadas durante seis años. Este estudio está fundamentado en 601 recolecciones de mixomicetes, obtenidas en el campo o por cultivo en cámara húmeda. En total, se han identificado 84 táxones que corresponden a 19 géneros. Se describe una nueva especie, Cribraria spinispora Lado & D.Wrigley sp. nov., además se registran por primera vez tres especies para Sudamérica y 22 para Perú. Las plantas endémicas, especialmente los cactus, han tenido una especial importancia como substrato para los mixomicetes. Se reafirma el predominio del orden Physarales T.Macbr. en zonas áridas. Se incluyen comentarios sobre algunas recolecciones, así como micrografías al MEB de algunas especies. Se realizó una evaluación estadística de la diversidad de mixomicetes en el cardonal y una comparación entre esta zona, la costa seca de Perú y otros ambientes neotropicales xéricos. Los resultados muestran que las zonas áridas son ricas en mixomicetes y que cada una tiene un conjunto exclusivo de especies. Las diferencias parecen estar relacionadas con las plantas anfitrionas

Parabens Promote Protumorigenic Effects in Luminal Breast Cancer Cell Lines With Diverse Genetic Ancestry

Context One in 8 women will develop breast cancer in their lifetime. Yet, the burden of disease is greater in Black women. Black women have a 40% higher mortality rate than White women, and a higher incidence of breast cancer at age 40 and younger. While the underlying cause of this disparity is multifactorial, exposure to endocrine disrupting chemicals (EDCs) in hair and other personal care products has been associated with an increased risk of breast cancer. Parabens are known EDCs that are commonly used as preservatives in hair and other personal care products, and Black women are disproportionately exposed to products containing parabens. Objective Studies have shown that parabens impact breast cancer cell proliferation, death, migration/invasion, and metabolism, as well as gene expression in vitro. However, these studies were conducted using cell lines of European ancestry; to date, no studies have utilized breast cancer cell lines of West African ancestry to examine the effects of parabens on breast cancer progression. Like breast cancer cell lines with European ancestry, we hypothesize that parabens promote protumorigenic effects in breast cancer cell lines of West African ancestry. Methods Luminal breast cancer cell lines with West African ancestry (HCC1500) and European ancestry (MCF-7) were treated with biologically relevant doses of methylparaben, propylparaben, and butylparaben. Results Following treatment, estrogen receptor target gene expression and cell viability were examined. We observed altered estrogen receptor target gene expression and cell viability that was paraben and cell line specific. Conclusion This study provides greater insight into the tumorigenic role of parabens in the progression of breast cancer in Black women

[Ca2+]_i oscillations in human sperm are triggered in the flagellum by membrane potential- sensitive activity of CatSper

Study question: How are progesterone (P4)-induced repetitive intracellular Ca2+ concentration ([Ca2+]i) signals (oscillations) in human sperm generated?Summary answer: P4-induced [Ca2+]i oscillations are generated in the flagellum by membrane-potential (Vm)-dependent Ca2+-influx through CatSper channels, which then induce secondary Ca2+ mobilisation at the sperm head/neck region.What is known already: A subset of human sperm display [Ca2+]i oscillations that regulate flagellar beating and acrosome reaction. Though pharmacological manipulations indicate involvement of stored Ca2+ in these oscillations, influx of extracellular Ca2+ is also required.Study design, size, duration: This was a laboratory study, that used >20 sperm donors and involved more than 100 separate experiments and analysis of more than 1,000 individual cells over a period of 2 years.Participants/materials, setting, methods: Semen donors and patients were recruited in accordance with local ethics approval from Birmingham University and Tayside ethics committees. [Ca2+]i responses and Vm of individual cells were examined by fluorescence imaging and whole-cell current clamp.Main results and the role of chance: P4-induced [Ca2+]i oscillations originated in the flagellum, spreading to the neck and head (latency of 1-2 s). K+-ionophore valinomycin (1 μM) was used to investigate the role of membrane potential (Vm). Direct assessment by whole-cell current-clamp confirmed that Vm in valinomycin-exposed cells was determined primarily by K+ equilibrium potential (EK) and was rapidly ‘reset’ upon manipulation of [K+]o. Pretreatment of sperm with valinomycin ([K+]o=5.4 mM) had no effect on the P4-induced [Ca2+] transient (P=0.95; 8 experiments), but application of valinomycin to P4-pretreated sperm suppressed activity in 82% of oscillating cells (n=257; P=5*10-55 compared to control) and significantly reduced both amplitude and frequency of persisting oscillations (p=0.0001). Upon valinomycin washout oscillations re-started in most cells. When valinomycin was applied in saline with elevated [K+] the inhibitory effect of valinomycin was reduced and was dependent on EK (P=10-25). Amplitude and frequency of [Ca2+]i oscillations that persisted in the presence of valinomycin showed similar sensitivity to EK (P<0.01). The CatSper inhibitor RU1968 (4.8 and 11 μM) caused immediate and reversible arrest of activity in36% and 96% of oscillating cells respectively (P<10-10). 300 μM quinidine which blocks the sperm K+ current (Ksper) completely inhibited [Ca2+]i oscillations.Large scale data: n/aLimitations, reasons for caution: This was an in-vitro study and caution must be taken when extrapolating these results to in vivo regulation of sperm.Wider implications of the findings: [Ca2+]i oscillations in human sperm are functionally important and their absence is associated with failed fertilisation at IVF. The data reported here provide new understanding of the mechanisms that underlie the generation (or failure) and regulation of these oscillations.Study funding/competing interest(s): ET was in receipt of a postgraduate scholarship from the CAPES Foundation (Ministry of Education, Brazil). The authors have no conflicts of interest

Linfadenectomía inguinal robot asistida (LIRA) para cáncer de pene

ResumenIntroducciónEl carcinoma de células escamosas es una entidad que ocupa el 2-5% de los tumores urogenitales, siendo por tanto poco frecuente, sin embargo en instituciones como la nuestra y por un alto volumen de pacientes y centro de referencia, se logra tener entre 5-7 casos por año. Dentro del tratamiento de estas lesiones se encuentra la linfadenectomía inguinal, la cual en la actualidad es realizada con mayor frecuencia con mínima invasión. Presentamos el caso de un paciente con carcinoma epidermoide de pene al que se le realizó linfadenectomía inguinal superficial y profunda con cirugía robot asistida.ObjetivoDescribir la técnica quirúrgica para linfadenectomía inguinal robot asistida en cáncer de pene.Presentación del casoHombre de 73 años con padecimiento con un año y 6 meses de evolución con aumento de volumen a nivel del glande; previa toma de biopsia se le realizó penectomía radical con uretrostomía perineal con resultado histopatológico de carcinoma epidermoide bien diferenciado verrucoso que infiltra el cuerpo esponjoso y la uretra (T3, N0, M0, G1); se realizó linfadenectomía inguinal robot asistida a las 4 semanas.ConclusionesLa linfadenectomía inguinal robot asistida es una técnica factible en centros en los que se cuente con dicha tecnología, logrando disminuir la morbilidad, el sangrado y la estancia hospitalaria, sin embargo tiene como desventaja el costo del procedimiento.AbstractIntroductionSquamous cell carcinoma is a rare tumor, making up from 2 to 5% of the urogenital tumors. However, because our hospital is a referral center that manages large numbers of patients, approximately 5-7 cases are seen per year. Inguinal lymph node dissection is one of the treatments for these lesions and is being performed more frequently as a minimally invasive procedure.ObjectiveOur aim was to describe the surgical technique for robotic-assisted inguinal lymphadenectomy in cancer of the penis. We present herein the case of a 73-year-old man with symptom progression of one year and 6 months and increased volume at the level of the glans penis. A biopsy was taken, after which he underwent radical penectomy with perineal urethrostomy. The histopathologic study reported well differentiated verrucous squamous cell carcinoma that invaded the corpus spongiosum and the urethra (T3N0M0G1). Four weeks later he underwent robotic-assisted inguinal lymphadenectomy of the superficial and deep lymph nodes.ConclusionsRobotic-assisted inguinal lymphadenectomy, aside from its high cost, is a feasible technique when carried out in specialized centers that reduces morbidity, blood loss, and hospital stay